Anticorps Vaccinia Virus (8118): sc-69950

Vaccinia Virus belongs to the poxvirus family of viruses. It contains double stranded DNA and was used as a vaccine to eradicate the smallpox disease. Fusion protein plays an important role in the entry of intracellular enveloped virus (IEV) into cells. In Vaccinia Virus, the fusion process is attributed to the action of a protein which is encoded by the Vaccinia Virus A27L gene. This protein plays an important role in the biology of the virus, acting in virus-to-cell and cell-to-cell fusions. The protein is required for the microtubule-dependent transport of intracellular mature virus particles and for the process of envelopment that leads to IEV formation. The N-terminus of this protein recognizes heparan sulfate on the cell surface and interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this protein are able to neutralize Vaccinia Virus infection and to identify other viral and cellular proteins which participate in the Vaccinia Virus entry process.

L'anticorps Vaccinia Virus préféré est l'Anticorps Vaccinia Virus (8115): sc-58210.