UBE2H Antibody (18-Z): sc-100620

UBE2H Antibody (18-Z) is a mouse monoclonal IgG2a antibody that detects UBE2H in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBE2H, also known as ubiquitin-conjugating enzyme E2H, UBC8, UBCH, UBCH2, or E2-20K, is a 183 amino acid protein that plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. UBE2H is primarily located in the cytoplasm, where UBE2H facilitates the covalent attachment of ubiquitin to target proteins, a process vital for marking proteins for degradation, thus preventing the accumulation of damaged or misfolded proteins that could lead to cellular dysfunction. UBE2H is known to interact with various proteins, including Histone H2A, highlighting UBE2H′s importance in chromatin remodeling and gene regulation. The conservation of UBE2H across species, with 100% identity to its mouse counterpart and 98% identity to homologs in frogs and zebrafish, underscores UBE2H′s fundamental role in cellular processes. Multiple isoforms of UBE2H arise from alternative splicing, which may contribute to UBE2H′s functional diversity and regulatory mechanisms in different biological contexts. Anti-UBE2H antibody (18-Z) is an invaluable tool for researchers studying the dynamics of protein degradation and the intricate networks of cellular regulation.

The preferred UBE2H antibody is UBE2H Antibody (G-2): sc-515567.