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Zyxin is a LIM domain-containing, zinc finger domain-containing, SH3 ligand-containing phosphoprotein that localizes to focal adhesion plaques and actin filament bundles. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein. TRIP6 interacts with the ligand binding domain of the thyroid receptor and is predominantly expressed in kidney, liver and lung. It interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a TNF- or IL-1-dependent manner. TRIP6 also interacts with TRAF2, a protein that is crucially involved in TNF signaling, as well as the IL-1 receptor, TLR2 and Nod1. Overexpression of TRIP6 facilitates NFkappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NFkappaB activation by TNF, IL-1, TLR2 or Nod1. Moreover, TRIP6 also potentiates RIP2- and Nod1-mediated ERK activation.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TRIP6 (C-5) | sc-166330 | 200 µg/ml | $316.00 | |||
TRIP6 (C-5): m-IgG Fc BP-HRP Kit | sc-540079 | 200 µg Ab; 10 µg BP | $354.00 | |||
TRIP6 (C-5): m-IgG1 BP-HRP Kit | sc-541891 | 200 µg Ab; 20 µg BP | $354.00 | |||
TRIP6 (C-5) peptide neutralisant | sc-166330 P | 100 µg/0.5 ml | $68.00 |