Anticorps TDRD10 (D-4): sc-398518

TDRD10 (Tudor domain-containing protein 10) is a 366 amino acid protein that contains one RRM (RNA recognition motif) domain and one Tudor domain. The TDRD10 gene encodes two alternatively spliced isoforms and maps to human chromosome 1q21.3. With roughly 3,000 genes that span about 260 million base pairs, chromosome 1 makes up approximately 8% of the human genome. There are also a large number of diseases associated with chromosome 1, notably, the rare aging disease Hutchinson-Gilford progeria which is associated with the LMNA gene that encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

L'anticorps TDRD10 préféré est l'Anticorps TDRD10 (C-7): sc-514046.