Sulochrin is a fungal metabolite isolated from both Penicillium sp. and Asperigillus, described to inhibit the degranulation, activation and chemotaxis of eosinophils. Additionally, Sulochrin has been shown to inhibit eosinophil O2 and IL-8 production, and LTC4 release. Studies suggest that Sulochrin inhibits the tube formation of HUVECs induced by the vascular endothelial growth factor (VEGF). Data from Aspergillus terreus lovastatin studies report Sulochrin as a co-metabolite during its fermentation.
1. Ohashi, H., et al. 1997. J. Antibiot. 50: 972-974. PMID: 9592574
2. Ohashi, H., et al. 1998. Inflamm. Res. 47: 409-415. PMID: 9831326
3. Ohashi, H., et al. 1999. Bioorg. Med. Chem. Lett. 9: 1945-1948. PMID: 10450959
4. Lee, H.J., et al. 2002. J. Antibiot. 55: 552-556. PMID: 12195960
5. Couch, R.D. and Gaucher, G.M. 2004. J. Biotechnol. 108: 171-178. PMID: 15129726