ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The SPA-1 (signal-induced proliferation-associated gene-1) protein is a principal RAP1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells. The SPA-1 gene is normally expressed in fetal and adult lymphohematopoietic tissues. Various types of mitogenic stimulation increase SPA-1 mRNA expression in normal lymphocytes. SPA-1 disrupts LFA-1-ICAM1-mediated adhesive interactions and subsequent T cell-receptor triggering and IL-2 production, possibly through inhibition of RAP1. Mice that are deficient for the SPA-1 gene develop age-dependent progression of T cell immunodeficiency followed by a spectrum of late onset myeloproliferative disorders, mimicking human chronic myeloid leukemia. SPA-1 also directly binds to AQP2 and plays a role in regulating AQP2 trafficking to the apical membrane.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SPA-1 (3) | sc-136189 | 50 µg/0.5 ml | $316.00 |