ACCÈS RAPIDE AUX LIENS
Snurportin-1, also known as SNUPN, KPNBL or RNUT1 (RNA U transporter 1), is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It specifically binds the terminal 2,2,7-m3G-cap at the 5' end of U snRNPs and functions to transport U snRNPs into the nucleus via an association with Importin β. The nuclear import of U snRNPs is an important step in the maturation of the spliceosome. The complex formed between Snurportin-1, U snRNP and Importin β is essential for nuclear import. Depending on the U snRNP (U1 or U2), Snurportin-1 may localize to Cajal bodies after nuclear import. In the nucleus, CRM1 binds to Snurportin-1 and is responsible for the recycling of Snurportin-1 back to the cytoplasm for additional rounds of U snRNP import.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Snurportin-1 (C-1) | sc-390155 | 200 µg/ml | $316.00 | |||
Snurportin-1 (C-1): m-IgGκ BP-HRP Kit | sc-535589 | 200 µg Ab; 40 µg BP | $354.00 | |||
Snurportin-1 (C-1): m-IgG1 BP-HRP Kit | sc-538885 | 200 µg Ab; 20 µg BP | $354.00 |