Sam 68 is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC gamma1. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC gamma1, Fyn and RasGAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC gamma1, Fyn or RasGAP, indicating that SLM-2 may not be an adapter protein for these proteins.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SLM-2 (E-9) | sc-398664 | 200 µg/ml | $316.00 | |||
SLM-2 (E-9): m-IgG Fc BP-HRP Kit | sc-538493 | 200 µg Ab; 10 µg BP | $354.00 | |||
SLM-2 (E-9): m-IgGκ BP-HRP Kit | sc-536118 | 200 µg Ab; 40 µg BP | $354.00 |