Anticorps SEI (SEI-17A): sc-66135

Staphylococcus represents a family of Gram-positive bacterial cocci that frequently live on the skin or in the nose of humans. Staphylococci produce β-lactamase, an enzyme which breaks down the β-lactam ring of the penicillin molecule, making it resistant to most penicillin and cephalosporins. Staphylococci cause a broad range of illnesses, from minor skin infections and abscesses to life-threatening diseases such as pneumonia, meningitis, endocarditis, septicemia and toxic shock syndrome (TSS). Toxic shock syndrome toxin-1 (TSST-1) is a Staphylococcal secreted exotoxin that is responsible for TSS, since it leads to non-specific binding of MHC II with T cell receptors, resulting in polyclonal T cell activation. Symptoms of TSS include high fever, accompanied by low blood pressure, malaise and confusion, which can rapidly progress to stupor, coma and multi-organ failure. Staphylococcus Enterotoxin I (SEI) is encoded in the egc operon of S. aureus, is associated with TSS, food poisoning, and various veterinary diseases.