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RNH1, the placental ribonuclease (RNase) inhibitor, is an acidic 460-amino acid protein which contains an unusually high content of leucine and cysteine residues. It is a member of a family of proteinaceous cytoplasmic RNase inhibitors that are expressed in many tissues and bind to both intracellular and extracellular RNases in the cytosol. RNH1 binds to a diverse variety of mammalian RNases and holds them in a latent form. It is also important in the control of mRNA turnover. RNH1inhibits angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily. Because angiogenesis is necessary for the growth and metastasis of tumors, RNH1 may play an important role in cancer gene therapy.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RNH1 (G-1) | sc-166485 | 200 µg/ml | $316.00 | |||
RNH1 (G-1): m-IgG Fc BP-HRP Kit | sc-540108 | 200 µg Ab; 10 µg BP | $354.00 | |||
RNH1 (G-1) peptide neutralisant | sc-166485 P | 100 µg/0.5 ml | $68.00 |