Anticorps Rhodanese (E-11): sc-365562

Rhodanese (also known as thiosulfate sulfurtransferase) is a mitochondrial matrix enzyme that is encoded by the nucleus. Rhodanese is a 297-residue polypeptide and has been proposed to play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes. Rhodanese was first identified in human red cells in 1956 and has been crystallized from beef liver. In mammals, most cyanide is converted to thiocyanate by the rhodanese. There is an association between Leber's optic neuropathy and deficiency of rhodanese activity in liver and rectal mucosa. Greatly reduced activity of this enzyme has been observed in the livers of two males with Leber optic atrophy from a well-studied Swiss family with five symptomatic persons in four generations. The red cell and tissue rhodanese are determined by separate genes, but more than one locus may be concerned with the synthesis of heterogeneous tissue isozymes. The gene which encodes rhodanese maps to human chromosome 22q11.2-qter.

L'anticorps Rhodanese préféré est l'Anticorps Rhodanese (G-7): sc-271883.