Upon activation, the small GTPase Rho D (also designated RhoHP1 and ARHD) contributes to rearrangement of the actin cytoskeleton and cell surface and also governs endosome motility and distribution. The effects of Rho D antagonize those of its family member, Rho A, by dissasembling actin stress fibers normally enhanced by Rho A. Additionally, Rho D disengages focal adhesions, resulting in retardation of cell migration. Accordingly, transfection of a constitutively active form of Rho D (designated Rho D G26V) reverses the invasive phenotype of G(α olf) induced cells, implying the possiblity of a therapeutic use for activated Rho D in counteracting tumor metastasis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rho D (H-1) | sc-376340 | 200 µg/ml | $316.00 | |||
Rho D (H-1): m-IgG2b BP-HRP Kit | sc-548595 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rho D (H-1) peptide neutralisant | sc-376340 P | 100 µg/0.5 ml | $68.00 |