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QIP1, also known as KPNA4 (karyopherin α4), IPOA3 (importin α3) or SRP3, is a member of the importin α family. It is involved in nuclear import and forms a complex with the importin β protein, karyopherin β1, functioning as its adapter protein. QIP1 binds to substrates containing nuclear localization signal (NLS) motifs, while karyopherin β1 facilitates the binding of the importin/substrate complex to the nuclear pore complex (NPC). Subsequently, the importin/substrate complex is translocated through the pore via a Ran-dependent mechanism. QIP1 contains one IBB domain at its hydrophilic N-terminus which is required for binding karyopherin β1 and ten ARM repeats in its hydrophobic central region. QIP1 is expressed at high levels in pancreas, lung, ovary, testis, small intestine, heart and skeletal muscle, exhibiting both cytoplasmic and nuclear localization.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps QIP1 (B-6) | sc-390535 | 200 µg/ml | $316.00 | |||
QIP1 (B-6): m-IgG Fc BP-HRP Kit | sc-540812 | 200 µg Ab; 10 µg BP | $354.00 | |||
QIP1 (B-6): m-IgG1 BP-HRP Kit | sc-542386 | 200 µg Ab; 20 µg BP | $354.00 |