In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. PSMD5 (proteasome (prosome, macropain) 26S subunit, non-ATPase 5), also known as S5B (S5 basic), is a regulatory component of the 26S proteasome. More specifically, PSMD5 is a subunit of the 19S regulator base and associates in a heterotrimer with PSMC1 and PSMC2. It contains nine di-leucine repeats and a motif similar to the tyrosine-based motif, suggesting a role for PSMD5 in trafficking, targeting and/or internalization.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PSMD5 (35-K) | sc-100461 | 100 µg/ml | $333.00 |