Anticorps PP2B-B2 (MH-94): sc-134423

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-Aα, PP2B-Aβ and PP2B-Aγ. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2. PP2B-B2, also known as PPP3R2 (protein phosphatase 3, regulatory subunit B, beta), PPP3RL, CBLP (calcineurin B-like protein) or CNBII (calcineurin BII), is a 170 amino acid protein that belongs to the calcineurin regulatory subunit family. Encoded by a gene that maps to human chromosome 9q31.1, PP2B-B2 is highly conserved. PP2B-B2 contains four EF-hand domains and exhibits testis-specific localization. PP2B-B2 is composed of a catalytic subunit (A) and a regulatory subunit (B), and functions as a regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.

L'anticorps PP2B-B1/2 préféré est l'Anticorps PP2B-B1/2 (D-1): sc-373803.