Anticorps Phd (G-7): sc-271769

Phosducin is a phototransducing protein that may participate in the feedback regulation of visual phototransduction or in the integration of photoreceptor metabolism. The human phosducin gene maps to chromosome 1q25-q31.1 and encodes a 246 amino acid protein, also designated Phd. Phd is primarily expressed in the retina and the pineal gland, while lower levels are present in tissues such as liver, spleen, striated muscle and the brain. Retinal Phd is found exclusively in the outer and inner segments of photoreceptor cells, including the synaptic and nuclear layers. Phd modulates the phototransduction cascade through high affinity binding and sequestration of G beta/gamma subunits of heterotrimeric G proteins. Neutralization of G beta/gamma by phosducin inhibits G protein-mediated signaling, since G alpha is unable to reassemble with G beta/gamma and provide a functional G protein trimer (G alpha/beta/gamma). In addition, phosducin can effectively slow down the mechanism of internalization of G protein-coupled opioid receptors.

L'anticorps Phd préféré est l'Anticorps Phd (E-1): sc-398752.