Anticorps PDZK1 (H-1): sc-390932
- L'Anticorps PDZK1 (H-1) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 419-446 près de C-terminus de PDZK1 d'origine mouse
- recommandé pour la détection de PDZK1 of mouse and rat origin and Diphor-1 of rat origin par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP et 1 BP-HRP">m-IgG1 BP-HRP sont les réactifs de détection secondaire préférés pour PDZK1 Antibody (H-1) for WB applications. Ces réactifs sont désormais proposés en lots avec PDZK1 Antibody (H-1)(voir les informations de commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
Proteins containing PDZ domains play a role in a wide array of biological functions including protein scaffolding, organization of ion channels, and signal transduction. The PDZ domain containing protein PDZK1 (known as Diphor-1 in rat) interacts with multiple targets, including MAP17 and cMOAT and also NaPi-IIa, which implicates PDZK1 in ion channel formation. PDZK1 localizes to the plasma membrane of epithelial cells, where it is able to interact simultaneously with more than one type of channel, by utilizing its 4 PDZ domains, and thus acts as an adaptor between different cell surface receptors. Furthermore, PDZK1 is markedly upregulated in human carcinomas of epithelial origin, and the cluster formed by its association with cMOAT and MAP17 may potentially play role in multidrug resistance. Therefore, PDZK1 may be a new target for cancers cells resistance to chemotherapeutic agents.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PDZK1 (H-1) | sc-390932 | 200 µg/ml | $316.00 | |||
PDZK1 (H-1): m-IgG Fc BP-HRP Kit | sc-540871 | 200 µg Ab; 10 µg BP | $354.00 | |||
PDZK1 (H-1): m-IgG1 BP-HRP Kit | sc-542431 | 200 µg Ab; 20 µg BP | $354.00 | |||
PDZK1 (H-1) peptide neutralisant | sc-390932 P | 100 µg/0.5 ml | $68.00 |