Anticorps Ndfip1 (NiNterm20-5): sc-53956
- Ndfip1 L'anticorps (NiNterm20-5) est un monoclonal de hamster d'Arménie. IgG2b fourni à 200 µg/ml
- élevé contre un peptide synthétique correspondant aux acides aminés 11-30 de Ndfip1
- recommandé pour la détection de Ndfip1 d'origine mouse par WB et FCM; non cross-reactif avec Ndfip2
- disponible conjugué soit à la phycoérythrine soit à la FITC pour IF, IHC(P) et FCM
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire Ndfip1 (NiNterm20-5). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
Nedd4 family interacting protein-1 (Ndfip1), also referred to as N4WBP5, is a member of a family of highly conserved proteins. It has three transmembrane domains in its carboxy terminal and two PY motifs in its amino terminal. Ndfip1 is a 221 amino acid, Golgi-associated protein that may play a role in Golgi structure and function. Ndfip1 binds the WW domains of a number of Nedd4 family members called HECT-type E3 ubiquitin ligases. Ndfip1 is strongly expressed in surviving neurons around a site of injury. This suggests that ubiquitination may be a possible survival strategy and Ndfip1 may act as a neuroprotective protein. Ndfip1 may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of Ndfip1 and its association with Itch may be promoted by T cell activation. Mice lacking Ndfip1 exhibit inactivation of Itch and accumulation of JunB causing them to die prematurely with severe skin and lung inflammation.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Ndfip1 (NiNterm20-5) | sc-53956 | 200 µg/ml | $316.00 | |||
Anticorps Ndfip1 (NiNterm20-5) FITC | sc-53956 FITC | 200 µg/ml | ||||
Anticorps Ndfip1 (NiNterm20-5) PE | sc-53956 PE | 200 µg/ml | $343.00 |