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HCF-1 is a cellular protein required by VP16, a viral tegument, to activate the herpes simplex virus (HSV) immediate-early genes. In addition to playing an essential role in cell proliferation, HCF-1 also functions as a coactivator for the basic leucine zipper transcription factor LZIP (also designated Luman or CREB3). Both LZIP and VP16 contain the binding motif (D/E) HXY (S/A), which is recognized by an amino terminal beta-propeller domain in HCF-1. LZIP, a member of the ATF/CREB family, is a type II membrane-associated glycoprotein that is ubiquitously expressed in adult and fetal tissues. LZIP associates with the endoplasmic reticulum, where it sequesters most of the cellular HCF-1. Like other CREB/ATF family members, LZIP activates transcription from genes containing cyclic AMP response elements (CREs). LZIP activity is repressed by the inhibitory interaction of HCLP-1.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LZIP (Q-61) | sc-100994 | 100µg/1.0ml | $316.00 |