Molecular structure of LY 379268, CAS Number: 191471-52-0
LY 379268 (CAS 191471-52-0)
See product citations (2)
Application:
LY 379268 is a highly selective group II mGlu receptor agonist
CAS Number:
191471-52-0
Purity:
≥98%
Molecular Weight:
187.15
Molecular Formula:
C7H9NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
LY 379268 is distinguished for its high selectivity as an agonist for the group II metabotropic glutamate receptors, particularly mGluR-2 and mGluR-3, demonstrating extremely low EC50 values of 2.69 and 4.48 nM, respectively. This specificity is over 80 times greater than for group I and group III mGluRs, emphasizing its unique role in targeting the glutamatergic system. The compound plays a role in advancing the understanding of the physiological and pathological significance of group II mGluRs within the central nervous system. Its targeted activation of these receptor subtypes provides an invaluable resource for exploring the complex dynamics of neurotransmission, neuronal adaptability, and the extensive role of glutamatergic pathways in neurobiological functions.
LY 379268 (CAS 191471-52-0) References
- Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268. | Cartmell, J., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 361: 39-46. PMID: 10651145
- Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. | Bond, A., et al. 2000. J Pharmacol Exp Ther. 294: 800-9. PMID: 10945827
- Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat. | Imre, G., et al. 2006. Pharmacol Biochem Behav. 84: 392-9. PMID: 16857251
- The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268. | Imre, G. 2007. CNS Drug Rev. 13: 444-64. PMID: 18078428
- Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys. | Bauzo, RM., et al. 2009. Pharmacol Biochem Behav. 94: 204-10. PMID: 19703487
- mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. | Di Liberto, V., et al. 2011. Neuropharmacology. 61: 638-45. PMID: 21619889
- The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats. | Crawford, JT., et al. 2013. Drug Alcohol Depend. 132: 414-9. PMID: 23953655
- Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. | Justinova, Z., et al. 2016. Psychopharmacology (Berl). 233: 1791-800. PMID: 26149611
- mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia. | Engel, M., et al. 2016. Psychopharmacology (Berl). 233: 1349-59. PMID: 26861891
- LY379268 Does Not Have Long-Term Procognitive Effects nor Attenuate Glutamatergic Signaling in AβPP/PS1 Mice. | Hascup, KN., et al. 2019. J Alzheimers Dis. 68: 1193-1209. PMID: 30909243
- The mGluR2/3 agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice. | Sokolenko, E., et al. 2019. J Psychopharmacol. 33: 1588-1599. PMID: 31580222
- Effects of the mGluR2/3 receptor agonist LY379268 on the reinforcing strength of cocaine in rhesus monkeys. | Czoty, PW., et al. 2020. Psychopharmacology (Berl). 237: 409-417. PMID: 31705165
- Rescue of BDNF expression by the thalamic parafascicular nucleus with chronic treatment with the mGluR2/3 agonist LY379268 may contribute to the LY379268 rescue of enkephalinergic striatal projection neurons in R6/2 Huntington's disease mice. | Wang, H., et al. 2021. Neurosci Lett. 763: 136180. PMID: 34416343
Activator of:
mGluR-2, mGluR-3, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 379268, 10 mg | sc-361247 | 10 mg | $318.00 | |||
LY 379268, 50 mg | sc-361247A | 50 mg | $1775.00 |