LUC7L Antibody (43-I): sc-101075
- LUC7L Antibody (43-I) is a mouse monoclonal IgG1 κ LUC7L antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant LUC7L of human origin
- recommended for detection of LUC7L of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LUC7L Antibody (43-I). This work is in progress.
LUC7L Antibody (43-I) is a mouse monoclonal IgG1 kappa light chain antibody that detects LUC7L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LUC7L antibody (43-I) is available as the non-conjugated format. LUC7L, also known as Luc7-like 1 or SR+89, is a 371 amino acid protein that plays a crucial role in pre-mRNA splicing and is a member of the Luc7 family, which is evolutionarily conserved from yeast to mammals. LUC7L protein is primarily localized in the nucleus, where LUC7L interacts with splicing factors and contributes to the regulation of gene expression. The arginine/serine-rich domain of LUC7L is essential for nuclear localization and function, highlighting LUC7L′s importance in the splicing process. Although LUC7L is ubiquitously expressed across various tissues, LUC7L is notably absent in adult skeletal muscle, where forced expression has been shown to inhibit myogenesis in vitro. The existence of three isoforms of LUC7L adds complexity to functional roles, with isoform 1 being the full-length protein, isoform 2 truncated at amino acid 325, and isoform 3 featuring a unique sequence variation in its N-terminal region. This diversity in isoforms may influence LUC7L′s interactions and functional outcomes in different cellular contexts.
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LUC7L Antibody (43-I) References:
- Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. | Tufarelli, C., et al. 2001. Genomics. 71: 307-14. PMID: 11170747
- Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. | Tufarelli, C., et al. 2003. Nat Genet. 34: 157-65. PMID: 12730694
- Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny. | Tufarelli, C., et al. 2004. Genome Res. 14: 623-30. PMID: 15060003
- Serine-arginine-rich nuclear protein Luc7l regulates myogenesis in mice. | Kimura, E., et al. 2004. Gene. 341: 41-7. PMID: 15474286
- Sequencing and mapping hemoglobin gene clusters in the Australian model dasyurid marsupial Sminthopsis macroura. | De Leo, AA., et al. 2005. Cytogenet Genome Res. 108: 333-41. PMID: 15627754
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LUC7L Antibody (43-I) | sc-101075 | 100 µg/ml | $322.00 |