ACCÈS RAPIDE AUX LIENS
Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. In fibrillar collagens and elastin, LOX catalyzes the lysine-derived cross-links of collagen fibrils and insoluble elastic fibers in the extracellular matrix. It can localize both to the nucleus and the cytoplasm. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like (LOXL1-LOXL4) proteins. LOXL3 is an extracellular protein that localizes specifically to sites of elastogenesis. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. In epithelial cells, overexpression of LOXL2 or LOXL3 may induce an epithelial-mesenchymal transitions process, an important element in tumor progression. LOXL3 is a widely expressed protein with highest levels of expression in placenta, small intestine, testis, heart, ovary and spleen.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LOXL3 (H-11) | sc-365285 | 200 µg/ml | $316.00 | |||
LOXL3 (H-11): m-IgG Fc BP-HRP Kit | sc-540326 | 200 µg Ab; 10 µg BP | $354.00 | |||
LOXL3 (H-11): m-IgG1 BP-HRP Kit | sc-542043 | 200 µg Ab; 20 µg BP | $354.00 |