Anticorps LEPREL4 (FR-1): sc-130442
- L'Anticorps LEPREL4 (FR-1) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 100 µg/ml
- dirigé contre la NOL55 recombinante d'origine human
- recommandé pour la détection de LEPREL4 d'origine human par WB et IP
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire LEPREL4 (FR-1). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
LEPREL4 (leprecan-like protein 4), also known as SC65 (synaptonemal complex protein SC65) or NOL55 (nucleolar autoantigen No55), is a 437 amino acid protein that belongs to the leprecan family. LEPREL4 is found specifically in the granular component of the nucleolus and during mitosis is found on the surface of chromosomes. LEPREL4 is post-translationally phosphorylated at tyrosine 234 and is encoded by a gene that maps to human chromosome 17. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LEPREL4 (FR-1) | sc-130442 | 100 µg/ml | $333.00 |