Anticorps KRIT1 (8-RY2): sc-134376
- KRIT1 anticorps (8-RY2) est un monoclonal de souris IgG2aλ, cité dans 1 publications, fourni en 100 µg/ml
- dirigé contre la KRIT1 recombinante d'origine human
- recommandé pour la détection de KRIT1 d'origine human par WB, IP et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire KRIT1 (8-RY2). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
The Krev interaction-trapped 1 (KRIT1) gene encodes a 529 amino acid microtubule-associated protein. Specifically, during interphase, KRIT1 localizes along the length of microtubules, whereas during metaphase it localizes on spindle pole bodies and on the mitotic spindle. During later phases of mitosis, KRIT1 localizes to the midbody where plus ends from dividing cells overlap. KRIT1 interacts with both Krev1 and integrin cytoplasmic domain-associated protein-1 alpha (ICAP1 alpha), suggesting that KRIT1 may help determine endothelial cell shape and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structure. In addition, KRIT1 mutations are implicated in individuals with Cerebral Cavernous Malformations (CCM). CCMs are capillaro-venous abnormalities located mostly within the central nervous system, and occasionally within the skin and/or retina. CCMs may occur either sporadically or as an autosomal dominant condition and can result in cerebral hemorrhages, strokes and seizures.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps KRIT1 (8-RY2) | sc-134376 | 100 µg/ml | $333.00 |