ACCÈS RAPIDE AUX LIENS
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IP6K1 (E-11) | sc-376290 | 200 µg/ml | $316.00 | |||
IP6K1 (E-11): m-IgG2a BP-HRP Kit | sc-546058 | 200 µg Ab; 10 µg BP | $354.00 |