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IgD chain C (Ig delta chain C region) is an allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a single-pass type I membrane protein. A member of the adaptive immune system, IgD antibodies are monomers expressed by activated B cells. Containing 3 Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14 within the human heavy chain locus, lying on the 3′ side of the IgM chain C region from the V-D-J cassette. Polyadenylation at certain sites along the heavy chain locus likely effects the mechanism that determines the alternative splicing event which results in the expression of either IgD chain C or IgM chain C. Some studies have suggested that antigenic coactivation of IgD+ B cells can have a negative influence on bone resorption during infectious events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IgD chain C (E-11) | sc-393537 | 200 µg/ml | $316.00 | |||
IgD chain C (E-11): m-IgG Fc BP-HRP Kit | sc-538240 | 200 µg Ab; 10 µg BP | $354.00 | |||
IgD chain C (E-11): m-IgGκ BP-HRP Kit | sc-535814 | 200 µg Ab; 40 µg BP | $354.00 | |||
IgD chain C (E-11): m-IgG2a BP-HRP Kit | sc-548244 | 200 µg Ab; 10 µg BP | $354.00 |