ACCÈS RAPIDE AUX LIENS
HIP1 (Huntingtin interacting protein 1), a membrane-associated protein, and HIP2 bind specifically to the N-terminus of human Huntingtin. HIP1 and HIP2 are ubiquitously expressed in different brain regions at low levels and exhibit nearly identical subcellular fractionation as Huntingtin. The Huntingtin-HIP1 interaction is inversely correlated to the polyglutamine length in Huntingtin, suggesting that loss of normal Huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. Conversely, the Huntingtin-HIP2 interaction is not affected by the polyglutamine length in the Huntingtin protein. However, both HIP1 and HIP2 play an important role in the pathogenesis of Huntington disease (HD).
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HIP2 (C-5) | sc-390138 | 200 µg/ml | $316.00 | |||
HIP2 (C-5): m-IgG Fc BP-HRP Kit | sc-540762 | 200 µg Ab; 10 µg BP | $354.00 | |||
HIP2 (C-5): m-IgG1 BP-HRP Kit | sc-542354 | 200 µg Ab; 20 µg BP | $354.00 |