H2-I/Abβ Antibody (25-9-3): sc-52537

H2-I/Abβ Antibody (25-9-3) is a mouse monoclonal IgM antibody that detects H2-I/Ab beta protein of mouse origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-H2-I/Ab beta antibody (25-9-3) is available as the non-conjugated format. H2-I/Ab beta protein plays a crucial role in the immune system as a component of the major histocompatibility complex (MHC) class II molecules, which are essential for the adaptive immune response. MHC class II molecules are primarily located on the surface of antigen-presenting cells, such as B cells, macrophages, and dendritic cells, where they bind and present foreign peptides to CD4+ T cells. This interaction is vital for the activation of T lymphocytes, which orchestrate the immune response against pathogens. H2-I/Ab beta′s ability to present a diverse array of peptides is influenced by its polymorphic nature, allowing for a tailored immune response to various antigens. Additionally, MHC class II molecule expression can be induced by interferon-g, enhancing the immune system′s ability to respond to infections. Understanding H2-I/Ab beta′s function and importance is essential for research into immune responses and potential therapeutic applications in immunology.

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H2-I/Abβ Antibody (25-9-3) References:

1. Mechanism of I-Abeta gene expression.  |  Lloberas, J., et al. 1999. Microbes Infect. 1: 935-41. PMID: 10614012
2. Heterogeneity of T cell clones specific for a single indirect alloantigenic epitope (I-Ab/H-2Kd54-68) that mediate transplant rejection.  |  Honjo, K., et al. 2000. Transplantation. 70: 1516-24. PMID: 11118099
3. Presentation of antigens by MHC class II molecules: getting the most out of them.  |  Villadangos, JA. 2001. Mol Immunol. 38: 329-46. PMID: 11684289
4. Prevention of type 1 diabetes by gene therapy.  |  Tian, C., et al. 2004. J Clin Invest. 114: 969-78. PMID: 15467836
5. Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon.  |  Larhammar, D., et al. 1983. Cell. 34: 179-88. PMID: 6411350
6. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.  |  Ozato, K. and Sachs, DH. 1981. J Immunol. 126: 317-21. PMID: 6935293
7. Assembly, transport, and function of MHC class II molecules.  |  Cresswell, P. 1994. Annu Rev Immunol. 12: 259-93. PMID: 8011283
8. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.  |  Muhlethaler-Mottet, A., et al. 1997. EMBO J. 16: 2851-60. PMID: 9184229
9. An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands.  |  Macleod, D., et al. 1998. Mol Cell Biol. 18: 4433-43. PMID: 9671453

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-H2-I/Abβ Antibody (25-9-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-H2-I/Abβ Antibody (25-9-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

H2-I/Abβ Antibody (25-9-3) Specifications

Alternate Product Name: H2-I/Abβ

Product Clone Name: 25-9-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: H2-I/Abβ

Epitope Species: mouse

Product Reactivity/Detection: MHC class II H2-I/Abβ

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for H2-I/Abβ Antibody (25-9-3): N/A

The preferred H2-I-A/I-E antibody is H2-I-A/I-E Antibody (M5/114): sc-23940.