H2-I/Ab Antibody (28-16-8S): sc-59197
- H2-I/Ab Antibody (28-16-8S) is a mouse monoclonal IgM H2-I/Ab antibody provided at 100 µg/ml
- raised against MHC Class II H2-I/Ab of mouse origin
- recommended for detection of MHC class II H2-I/Ab of mouse origin by FCM; may cross-react with H2-I/Ad
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-I/Ab Antibody (28-16-8S). This work is in progress.
H2-I/Ab Antibody (28-16-8S) is a mouse monoclonal IgM antibody that detects the H2-I/Ab protein of mouse origin by flow cytometry (FCM). Anti-H2-I/Ab antibody (28-16-8S) is available as the non-conjugated format, providing researchers with a reliable tool for studying the immune response. H2-I/Ab protein plays a crucial role in the immune system as a member of the major histocompatibility complex (MHC) class II molecules, which are essential for the presentation of antigens to CD4+ T cells. These molecules are primarily located on the surface of antigen-presenting cells (APCs) such as B cells, macrophages, and dendritic cells, facilitating the activation of T lymphocytes and the subsequent immune response. H2-I/Ab′s ability to bind and present foreign peptides is vital for the recognition of pathogens, making H2-I/Ab a key player in adaptive immunity. H2-I/Ab protein is known to interact with various other proteins, including CD4, which enhances T cell activation and signaling. Understanding H2-I/Ab′s interactions and functions is important for developing therapeutic strategies in immunology and for advancing our knowledge of immune system dynamics.
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H2-I/Ab Antibody (28-16-8S) References:
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- Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. | Muhlethaler-Mottet, A., et al. 1997. EMBO J. 16: 2851-60. PMID: 9184229
- An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands. | Macleod, D., et al. 1998. Mol Cell Biol. 18: 4433-43. PMID: 9671453
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-I/Ab Antibody (28-16-8S) | sc-59197 | 100 µg/ml | $322.00 |