GSTO1 (glutathione S-transferase omega 1), also known as p28 or GSTTLp28, is a 241 amino acid protein that localizes to the cytoplasm and contains both an N-terminal and a C-terminal GST domain. Expressed ubiquitously with highest expression in heart, liver and skeletal muscle, GSTO1 exists as a homodimer that functions as both a glutathione-dependent thiol transferase and a dehydroascorbate reductase. Specifically, GSTO1 catalyzes the reaction of glutathione with a wide variety of organic compounds to form thioethers, a process that is essential for the metabolism and detoxification of a variety of xenobiotics and carcinogens. Polymorphisms in the gene encoding GSTO1 may be associated with the development of childhood acute lymphoblastic leukemia, Parkinson's disease and Alzheimer disease. GSTO2 (glutathione S-transferase omega-2) is related to GSTO1 and is expressed in a variety of tissues throughout the body where it functions to catalyze the conversion of RX and glutathione to HX and R-S-glutathione.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GSTO1/2 (D-8) | sc-166039 | 200 µg/ml | $316.00 | |||
GSTO1/2 (D-8): m-IgG Fc BP-HRP Kit | sc-537432 | 200 µg Ab; 10 µg BP | $354.00 | |||
GSTO1/2 (D-8): m-IgGκ BP-HRP Kit | sc-534696 | 200 µg Ab; 40 µg BP | $354.00 | |||
GSTO1/2 (D-8): m-IgG1 BP-HRP Kit | sc-545182 | 200 µg Ab; 20 µg BP | $354.00 |