Anticorps GRF-1 (2389D3a): sc-81094
- L'anticorps GRF-1 2389D3a est un monoclonal IgG1 de souris fourni en 100 µg/ml
- soulevée contre une protéine recombinante correspondant à une région interne de GRF-1 d'origine human.
- recommandé pour la détection de GRF-1 d'origine mouse, rat et human par WB et IP
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire GRF-1 (2389D3a). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The glucocorticoid receptor (GR) is a ligand-dependent, transactivating regulatory protein that is a member of the nuclear receptor superfamily. GRF-1 (glucocorticoid receptor DNA-binding factor 1), also known as p190RhoGAP or simply p190, is a transcriptional regulator which binds to the promoter region of the glucocorticoid receptor gene and represses its expression. By repressing GR expression, GRF-1 acts to down-regulate Rho signaling, thereby mediating both actin cytoskeletal rearrangements and cell cycle events. Through its GAP domain, GRF-1 is thought to affect cytokinesis by regulating Rho activity; a regulation that is controlled by the ubiquination of the GTP binding region and subsequent degradation of GRF-1. Additionally, GRF-1 plays an important role in oligodendrocyte differentiation, a process that is absent in malignant glioma tumors, implicating GRF-1 as a possible tumor suppressor. GRF-1 expression is regulated by glucocorticoids and the expressed protein exists as two isoforms produced by alternative splicing events.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GRF-1 (2389D3a) | sc-81094 | 100 µg/ml | $333.00 |