Molecular structure of Desloratadine, CAS Number: 100643-71-8
Desloratadine (CAS 100643-71-8)
See product citations (3)
Application:
Desloratadine is a potent and selective H1-receptor agonist
CAS Number:
100643-71-8
Purity:
97%
Molecular Weight:
310.82
Molecular Formula:
C19H19ClN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by Desloratadine is reversible and that, over time, it dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFkappaB activation in primary bronchial and transformed respiratory epithelial cells in vitro.
Desloratadine (CAS 100643-71-8) References
- Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug. | Agrawal, DK. 2001. Expert Opin Investig Drugs. 10: 547-60. PMID: 11424898
- Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells. | Papi, A., et al. 2001. J Allergy Clin Immunol. 108: 221-8. PMID: 11496238
- Desloratidine for the treatment of chronic urticaria. | Monroe, EW. 2002. Skin Therapy Lett. 7: 1-2, 5. PMID: 12548327
- Desloratadine: a nonsedating antihistamine. | Limon, L. and Kockler, DR. 2003. Ann Pharmacother. 37: 237-46; quiz 313-6. PMID: 12549956
- Desloratadine partially inhibits the augmented bacterial responses in the sinuses of allergic and infected mice. | Kirtsreesakul, V., et al. 2004. Clin Exp Allergy. 34: 1649-54. PMID: 15479283
- Desloratadine inhibits human skin mast cell activation and histamine release. | Weller, K. and Maurer, M. 2009. J Invest Dermatol. 129: 2723-6. PMID: 19516262
- Influence of desloratadine on selected oxidative stress markers in patients between 3 and 10 years of age with allergic perennial rhinitis. | Sadowska-Woda, I., et al. 2010. Eur J Pharmacol. 640: 197-201. PMID: 20493834
- Desloratadine citrate disodium injection, a potent histamine H(1) receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades. | Chen, M., et al. 2015. Eur J Pharmacol. 767: 98-107. PMID: 26455479
- Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. | Li, S., et al. 2020. Arch Immunol Ther Exp (Warsz). 68: 6. PMID: 32076842
- Desloratadine and loratadine use associated with improved melanoma survival. | Fritz, I., et al. 2020. Allergy. 75: 2096-2099. PMID: 32171023
- The effect of desloratadine on ischemia reperfusion induced oxidative and inflammatory renal injury in rats. | Kocaturk, H., et al. 2020. Ren Fail. 42: 531-538. PMID: 32524906
- Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats. | Troyanova-Wood, M., et al. 2021. J Biophotonics. 14: e202000269. PMID: 32951319
- Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction. | Lu, J., et al. 2021. Aging Cell. 20: e13286. PMID: 33369003
- Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine. | Fritz, I., et al. 2021. Transl Oncol. 14: 101029. PMID: 33550204
Inhibitor of:
Histamine H1 Receptor.Activator of:
Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desloratadine, 100 mg | sc-202133 | 100 mg | $89.00 | |||
Desloratadine, 500 mg | sc-202133A | 500 mg | $400.00 |