Les Produits Chimiques ChemCruz™
Cyclophilin Inhibitors pour l'analyse fonctionnelle des réponses cellulaires avec Cyclophilin
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CyPB Antibody (k2E2) is a high quality monoclonal CyPB antibody (also designated CyPB antibody) suitable for the detection of the CyPB protein of mouse, rat and human origin. CyPB Antibody (k2E2) is available as the non-conjugated anti-CyPB antibody. The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the Cyclosporin A and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with CyPB (k2E2): sc-130626 antibody?
Posée par: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Rated 1 de
weak bandsWe needed different size house keeping controls. it did however give a weak double band after longer exposure than we normal use. We will not continue using this antibody.
Date de publication: 2018-04-09
Rated 5 de
Excellent antibody - Very clearAntibody works well - clear, specific band for western blot with 25 ug U87 cell lysates at 1:1000 primary antibody dilution.
Date de publication: 2017-09-11
Rated 5 de
Great bands seen in western blot analysisGreat bands seen in western blot analysis of CyPB expression in Hep G2 and HeLa whole cell lysates. -SCBT QC
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To place an order using RMB or to ship to mainland China, please visit www.scbio.cn