Date published: 2026-10-17

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α-actinin-4 抗体 (LW-M23): sc-134236

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说明书
  • α-actinin-4抗体(LW-M23)是小鼠单克隆IgG2a κ, 在9篇文献中引用,规格为100 µg/ml
  • 针对human重组α-actinin-4蛋白的抗原性氨基酸
  • 推荐用于 mouse, rat 和 human 来源的α-actinin-4 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成α-actinin-4 抗体 (LW-M23)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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血影蛋白基因家族编码多种细胞骨架蛋白,包括血影蛋白、肌营养不良蛋白和α-肌动蛋白。有四种组织特异性α-肌动蛋白,即α-肌动蛋白-1、α-肌动蛋白-2、α-肌动蛋白-3和α-肌动蛋白-4,它们定位于肌肉和非肌肉细胞,包括骨骼肌、心肌和平滑肌细胞,以及细胞骨架内。每个α-肌动蛋白蛋白含有一个肌动蛋白结合结构域、两个钙调素同源结构域、两个EF-手结构域和四个血影蛋白重复序列,它们通过这些结构域作为捆绑蛋白发挥作用,可以交联F-肌动蛋白,从而将肌动蛋白锚定到各种细胞内结构。编码α-肌动蛋白-4的基因缺陷是局灶节段性肾小球硬化1(FSGS1)的原因,FSGS1是一种常见的肾脏病变,其特征是肾功能下降,最终导致肾功能衰竭。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

α-actinin-4 抗体 (LW-M23) 参考文献:

  1. α-肌动蛋白 1 和α-肌动蛋白 4:在星形细胞瘤细胞的存活, 运动和 RhoA 信号传导中发挥着截然不同的作用。  |  Quick, Q. and Skalli, O. 2010. Exp Cell Res. 316: 1137-47. PMID: 20156433
  2. α-肌动蛋白4与乳腺癌的肿瘤发生。  |  Hsu, KS. and Kao, HY. 2013. Vitam Horm. 93: 323-51. PMID: 23810014
  3. 第五感:α-肌动蛋白-4的机械感受调节及其与癌症转移的相关性。  |  Thomas, DG. and Robinson, DN. 2017. Semin Cell Dev Biol. 71: 68-74. PMID: 28579451
  4. α-Actinin-4促进胃癌转移。  |  Liu, X. and Chu, KM. 2017. Lab Invest. 97: 1084-1094. PMID: 28581489
  5. Dynamin 2 与 α-actinin 4 相互作用,推动肿瘤细胞侵袭。  |  Burton, KM., et al. 2020. Mol Biol Cell. 31: 439-451. PMID: 31967944
  6. α-肌动蛋白-4在肌动蛋白重塑细菌感染过程中的定位。  |  Dhanda, AS., et al. 2021. Anat Rec (Hoboken). 304: 1400-1419. PMID: 33099893
  7. α-Actinin 4 链接肾集合管细胞中血管加压素对 Aquaporin-2 的短期和长期调控。  |  Ho, CH., et al. 2021. Front Physiol. 12: 725172. PMID: 34925053
  8. α-肌动蛋白4与肝癌的肿瘤发生。  |  Wang, G., et al. 2019. Transl Cancer Res. 8: 1374-1380. PMID: 35116880
  9. α-肌动蛋白-4将Shp2吸引到细胞黏附斑中,以增强足细胞中ROCK2的活性。  |  Tseng, CC., et al. 2022. Life Sci Alliance. 5: PMID: 36096674
  10. 紫杉霉素通过调节吉西他滨耐药性胰腺癌细胞中的α-肌动蛋白-4发挥抗增殖活性。  |  Lee, JH., et al. 2024. Biomol Ther (Seoul). 32: 123-135. PMID: 38148558

订购信息

产品名称产品编号规格价格数量收藏夹

α-actinin-4 抗体 (LW-M23)

sc-134236
100 µg/ml
$339.00

Can sc-134236: α-actinin-4 (LW-M23) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: cjMara
Thank you for your question. Yes, sc-134236: α-actinin-4 (LW-M23) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by FL from Good antibody for WB in humanGood antibody for WB in human -actinin-4 transfected 293T and HeLa whole cell lysates. -SCBT QC
Date published: 2015-05-30
Rated 4 out of 5 by NZ from Strong positive band detected via WB in HeLaStrong positive band detected via WB in HeLa nuclear extract. -SCBT QC
Date published: 2015-02-27
Rated 4 out of 5 by JT from Clear immunoperoxidase nuclear and cytoplasmicClear immunoperoxidase nuclear and cytoplasmic staining in formalin-fixed, paraffin-embedded human testis tissue. -SCBT QC
Date published: 2015-02-07
Rated 4 out of 5 by LR from Clean band seen in WB in AClean band seen in WB in A-673 whole cell lysate. -SCBT QC
Date published: 2015-01-14
Rated 4 out of 5 by HF from Good specificity in WB in MCF7 whole cell lysateGood specificity in WB in MCF7 whole cell lysate. -SCBT QC
Date published: 2015-01-14
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α-actinin-4 抗体 (LW-M23) is rated 4.0 out of 5 by 5.
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