Anticorps 15-LO2 (H-6): sc-166387
- L'Anticorps 15-LO2 (H-6) est un monoclonal de souris IgG2b κ, cité dans 1 publications, fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 423-452 au niveau d'une région interne de 15-LO2 d'origine human
- recommandé pour la détection de 15-LO2 splice variants a, b and c d'origine human par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP et 2b BP-HRP">m-IgG2b BP-HRP sont les réactifs de détection secondaire préférés pour 15-LO2 Antibody (H-6) pour les applications WB. Ces réactifs sont désormais proposés en lots avec 15-LO2 Antibody (H-6)(voir les informations de commande ci-dessous).
Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes, the synthesis of signalling molecules as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals, 12-LO and 15-LO, are classified with respect to their positional specificity of the dioxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation. 15-lipoxygenase, type II (15-LO2) is important for the conversion of arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. It is a cytoplasmic protein expressed primarily in cornea, lung, hair and prostate.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps 15-LO2 (H-6) | sc-166387 | 200 µg/ml | $316.00 | |||
15-LO2 (H-6): m-IgG Fc BP-HRP Kit | sc-540093 | 200 µg Ab; 10 µg BP | $354.00 | |||
15-LO2 (H-6): m-IgG2b BP-HRP Kit | sc-549772 | 200 µg Ab; 10 µg BP | $354.00 | |||
15-LO2 (H-6) peptide neutralisant | sc-166387 P | 100 µg/0.5 ml | $68.00 |