WAY 213613 is a strong, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). WAY 213613 exhibits no activity towards metabotropic and ionotropic glutamate receptors.
1. Dunlop, J., et al. 2005. Mol. Pharmacol. 68: 974-982. 2. Beart, P.M. and O'Shea, R.D. 2007. Br. J. Pharmacol. 150: 5-17.
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