VR1 (m2): 293 Lysate: sc-179742

VR1 (m2): 293 Lysate is derived from the 293 cell line engineered to express the mouse transient receptor potential vanilloid subtype 1 (VR1) channel. VR1, also known as TRPV1, is a non-selective cation channel primarily activated by capsaicin, the pungent compound in chili peppers, as well as by heat, protons, and endogenous lipid-derived molecules. This channel plays a crucial role in nociception, thermoregulation, and inflammatory processes. The 293 cell line is widely used in research due to its high transfection efficiency and robust protein expression capabilities, making it suitable for generating VR1 lysates. In scientific research, VR1 (m2): 293 Lysate serves as a valuable tool for studying the molecular mechanisms underlying VR1 channel function and regulation. Researchers utilize this lysate in various experimental assays, including electrophysiology, calcium imaging, and pharmacological studies, to investigate VR1 channel activation, desensitization, and modulation by intracellular signaling pathways. Moreover, VR1 (m2): 293 Lysate is employed to explore the physiological roles of VR1 in sensory neurons, such as its involvement in pain sensation, thermosensation, and neurogenic inflammation. By utilizing this lysate, researchers can explain the signaling cascades and physiological functions associated with the VR1 channel, contributing to a better understanding of sensory transduction mechanisms.