Molecular structure of Tacrine Hydrochloride, CAS Number: 1684-40-8
Tacrine Hydrochloride (CAS 1684-40-8)
See product citations (6)
Alternate Names:
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride; Cognex; Romotal
Application:
Tacrine Hydrochloride is an anticholinesterase (AChE) inhibitor
CAS Number:
1684-40-8
Purity:
≥98%
Molecular Weight:
234.70
Molecular Formula:
C13H14N2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tacrine Hydrochloride may act to reversibly inhibit acetylcholine esterase (AChE). This compound has been reported to display hepatotoxicity, more specifically causing pericentral necrosis and fat degeneration of hepatocytes. Additionally, tacrine hydrochloride has demonstrated the ability to cause a decrease in liver glycogens and an increase in Heme Oxygenase 1. Other experiments suggest that tacrine hydrochloride causes functional and morphological changes in the endoplasmic reticulum, ribosome, and mitochondria of the liver via DNA synthesis impairment. Tacrine hydrochloride is an inhibitor of butyrylcholinesterase (BChE).
Tacrine Hydrochloride (CAS 1684-40-8) References
- Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine. | Lupp, A., et al. 2010. Arzneimittelforschung. 60: 229-37. PMID: 20533758
- Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. | Summers, WK., et al. 1986. N Engl J Med. 315: 1241-5. PMID: 2430180
- Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. | Galdeano, C., et al. 2018. Molecules. 23: PMID: 29534488
- An improved immobilized enzyme reactor-mass spectrometry-based label free assay for butyrylcholinesterase ligand screening. | Vilela, AFL., et al. 2018. Anal Biochem. 549: 53-57. PMID: 29550345
- Lysozyme amyloid fibrillization in presence of tacrine/acridone-coumarin heterodimers. | Ulicna, K., et al. 2018. Colloids Surf B Biointerfaces. 166: 108-118. PMID: 29550545
- Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice. | Chen, H., et al. 2018. Metab Brain Dis. 33: 1131-1139. PMID: 29564727
- Protein-mimicking nanowire-inspired electro-catalytic biosensor for probing acetylcholinesterase activity and its inhibitors. | Zhang, Q., et al. 2018. Talanta. 183: 258-267. PMID: 29567174
- A new flavonoid from the leaves of Atalantia monophylla (L.) DC. | Posri, P., et al. 2019. Nat Prod Res. 33: 1115-1121. PMID: 29600742
- Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity. | Sabolová, D., et al. 2018. J Appl Toxicol. 38: 1377-1387. PMID: 29624715
- Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening. | Fabini, E., et al. 2018. J Pharm Biomed Anal. 155: 177-184. PMID: 29635172
- Therapeutic Potential of Multifunctional Tacrine Analogues. | Przybyłowska, M., et al. 2019. Curr Neuropharmacol. 17: 472-490. PMID: 29651948
- Tacrine derivatives stimulate human glioma SF295 cell death and alter important proteins related to disease development: An old drug for new targets. | Costa Nunes, F., et al. 2018. Biochim Biophys Acta Gen Subj. 1862: 1527-1536. PMID: 29704527
- Endogenous acetylcholine regulates neuronal and astrocytic vascular endothelial growth factor expression levels via different acetylcholine receptor mechanisms. | Kimura, K., et al. 2018. Neurochem Int. 118: 42-51. PMID: 29705288
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. | Liu, W., et al. 2018. Bioorg Med Chem. 26: 3117-3125. PMID: 29729987
- Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells. | Robertson, DG., et al. 1998. Arch Toxicol. 72: 362-71. PMID: 9657284
Inhibitor of:
AChE, AGPS, BChE, CHT1, CYP1A2, dNT-2, Enzyme, PRiMA, and ZNF77.Activator of:
AChRα1, and CPM.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tacrine Hydrochloride, 1 g | sc-200172 | 1 g | $42.00 | |||
Tacrine Hydrochloride, 5 g | sc-200172A | 5 g | $141.00 |