SCGN Antibody (F-9): sc-374355

SCGN Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SCGN protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SCGN (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SCGN protein, also known as Secretagogin, CALBL, setagin, or SECRET, is a 276 amino acid cytoplasmic protein characterized by six EF-hand domains, which are critical for calcium binding and signaling. SCGN is predominantly expressed in tissues such as the stomach, thyroid, colon, brain, and neuroendocrine cells, where SCGN plays a significant role in regulating calcium homeostasis and cellular signaling pathways. SCGN′s ability to modulate calcium storage pools within cells is essential for function in cell proliferation and potassium chloride-mediated calcium flux events. Through influencing these processes, SCGN may serve as a negative regulator of growth and differentiation rates, thereby indirectly inhibiting cell replication. anti-SCGN antibody (F-9) serves as a valuable tool for researchers studying the intricate roles of calcium-binding proteins in various biological contexts.

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SCGN Antibody (F-9) References:

1. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein.  |  Wagner, L., et al. 2000. J Biol Chem. 275: 24740-51. PMID: 10811645
2. Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.  |  Gartner, W., et al. 2001. Cereb Cortex. 11: 1161-9. PMID: 11709487
3. Secretagogin is a novel marker for neuroendocrine differentiation.  |  Birkenkamp-Demtröder, K., et al. 2005. Neuroendocrinology. 82: 121-38. PMID: 16449819
4. Binding of calcium ions and SNAP-25 to the hexa EF-hand protein secretagogin.  |  Rogstam, A., et al. 2007. Biochem J. 401: 353-63. PMID: 16939418
5. Identification and characterization of secretagogin promoter activity.  |  Skovhus, KV., et al. 2006. Scand J Immunol. 64: 639-45. PMID: 17083620
6. Secretagogin is a new neuroendocrine marker in the human prostate.  |  Adolf, K., et al. 2007. Prostate. 67: 472-84. PMID: 17285592
7. New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog.  |  Gartner, W., et al. 2007. Am J Physiol Endocrinol Metab. 293: E347-54. PMID: 17426113
8. Secretagogin expression in tumours of the human brain and its coverings.  |  Pipp, I., et al. 2007. APMIS. 115: 319-26. PMID: 17504298
9. SCGN deficiency results in colitis susceptibility.  |  Sifuentes-Dominguez, LF., et al. 2019. Elife. 8: PMID: 31663849
10. SCGN-regulated Stage-wise SNARE Assembly: Novel Insight into Synaptic Exocytosis.  |  Lv, Y., et al. 2020. Neurosci Bull. 36: 1576-1578. PMID: 33025412
11. SCGN deficiency is a risk factor for autism spectrum disorder.  |  Liu, Z., et al. 2023. Signal Transduct Target Ther. 8: 3. PMID: 36588101
12. SCGN and STAT3 expressions are associated with the prognosis of ccRCC.  |  Lai, C., et al. 2023. Pathol Res Pract. 252: 154940. PMID: 37977033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCGN Antibody (F-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SCGN Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCGN Antibody (F-9) Specifications

Alternate Product Name: SCGN

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 186-276

Epitope Target: SCGN

Epitope Species: human

Product Reactivity/Detection: SCGN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SCGN Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin