RGMc Antibody (1C12): sc-293393
- RGMc Antibody (1C12) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against amino acids 93-173 of RGMc of human origin
- recommended for detection of RGMc of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RGMc Antibody (1C12). This work is in progress.
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RGMc Antibody (1C12) is a mouse monoclonal IgG2a antibody that detects RGMc in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RGMc, also known as Hemojuvelin, plays a crucial role in iron homeostasis by participating in the signaling pathway that activates hepcidin, a key regulator of iron absorption in the gut. This interaction is vital for maintaining appropriate iron levels in the body, as excessive iron can lead to toxicity and organ damage. The importance of RGMc is underscored by its association with juvenile hemochromatosis, an autosomal recessive disorder caused by defects in the gene encoding RGMc, which results in severe iron overload. RGMc is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor, facilitating its function in cellular signaling. Anti-RGMc antibody (1C12) is an essential tool for researchers studying iron metabolism and related disorders, providing insights into the molecular mechanisms underlying these critical biological processes.
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RGMc Antibody (1C12) References:
- Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. | Krijt, J., et al. 2004. Blood. 104: 4308-10. PMID: 15315977
- Complex biosynthesis of the muscle-enriched iron regulator RGMc. | Kuninger, D., et al. 2006. J Cell Sci. 119: 3273-83. PMID: 16868025
- Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin. | Kuns-Hashimoto, R., et al. 2008. Am J Physiol Cell Physiol. 294: C994-C1003. PMID: 18287331
- Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. | Severyn, CJ., et al. 2009. Biochem J. 422: 393-403. PMID: 19698085
- RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling. | Siebold, C., et al. 2017. Trends Cell Biol. 27: 365-378. PMID: 28007423
- Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts. | Torti, SV., et al. 2016. Clin Exp Pharmacol. 6: PMID: 28203489
- Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors. | Sanchez-Duffhues, G., et al. 2020. Bone. 138: 115472. PMID: 32522605
- Hydrocephalus and diffuse choroid plexus hyperplasia in primary ciliary dyskinesia-related MCIDAS mutation. | Robson, EA., et al. 2020. Neurol Genet. 6: e482. PMID: 32802948
- Role of RGMc as a Neogenin Ligand in Follicular Development in the Ovary. | Kim, YJ., et al. 2021. Biomedicines. 9: PMID: 33801938
- The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. | Wang, XF., et al. 2024. Nat Commun. 15: 1037. PMID: 38310100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RGMc Antibody (1C12) | sc-293393 | 100 µg/ml | $322.00 |