Molecular structure of Pirfenidone, CAS Number: 53179-13-8
Pirfenidone (CAS 53179-13-8)
See product citations (6)
Alternate Names:
5-Methyl-1-phenyl-2-(1H)-pyridone
Application:
Pirfenidone is an antifibrotic and antioxidant small molecule
CAS Number:
53179-13-8
Purity:
≥99%
Molecular Weight:
185.23
Molecular Formula:
C12H11NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pirfenidone is a small molecule antifibrotic agent. In pulmonary fibrosis studies, Pirfenidone is shown to block collagen production and mitigate the presentation of bleomycin- and cyclophosphamide-induced fibrosis. This intervention appears in part on the transcriptional level, with Pirfenidone exposure correlating to a significant decrease in levels of procollagen I and III gene-assoicated messenger RNA. The antioxidant radical-scavenging activity additionally demonstrated by Pirfenidone suggests a role in protecting against lipid peroxidation, and may attribute to the antifibrotic property of the compound.
Pirfenidone (CAS 53179-13-8) References
- Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. | Iyer, SN., et al. 1999. J Pharmacol Exp Ther. 289: 211-8. PMID: 10087006
- Effects of pirfenidone on the generation of reactive oxygen species in vitro. | Giri, SN., et al. 1999. J Environ Pathol Toxicol Oncol. 18: 169-77. PMID: 15281229
- Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. | Mei, S., et al. 2005. J Pharmacol Exp Ther. 313: 379-88. PMID: 15608079
- Pirfenidone for the treatment of idiopathic pulmonary fibrosis. | Antoniu, SA. 2006. Expert Opin Investig Drugs. 15: 823-8. PMID: 16787145
- Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis. | Azuma, A. 2010. Expert Rev Respir Med. 4: 301-10. PMID: 20524912
- Pirfenidone in idiopathic pulmonary fibrosis. | Maher, TM. 2010. Drugs Today (Barc). 46: 473-82. PMID: 20683502
- Antifibrotic activities of pirfenidone in animal models. | Schaefer, CJ., et al. 2011. Eur Respir Rev. 20: 85-97. PMID: 21632796
- Pirfenidone: significant treatment effects in idiopathic pulmonary fibrosis. | Hilberg, O., et al. 2012. Clin Respir J. 6: 131-43. PMID: 22697264
- The role of pirfenidone in the treatment of idiopathic pulmonary fibrosis. | Cottin, V. 2013. Respir Res. 14 Suppl 1: S5. PMID: 23734908
- Pirfenidone. First, do no harm. | . 2013. Prescrire Int. 22: 117-9. PMID: 23819168
- Pirfenidone for the treatment of idiopathic pulmonary fibrosis. | Xaubet, A., et al. 2014. Expert Opin Pharmacother. 15: 275-81. PMID: 24308635
- Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitus. | Avila, G., et al. 2014. Cell Calcium. 56: 428-35. PMID: 25108569
- Pirfenidone for the treatment of idiopathic pulmonary fibrosis. | Poletti, V., et al. 2014. Expert Rev Respir Med. 8: 539-45. PMID: 25113033
- Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. | Kehrer, JP. and Margolin, SB. 1997. Toxicol Lett. 90: 125-32. PMID: 9067480
- Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production. | Lee, BS., et al. 1998. J Clin Endocrinol Metab. 83: 219-23. PMID: 9435445
Inhibitor of:
β ig-h3, Asporin, COL11A1, COL13A1, COL14A1, COL15A1, COL16A1, COL1A1, COL1A2, COL22A1, COL28A1, COL3A1, COL5A3, COL6A, COL6A6, COL8A1, COL9A1, CRIM1, FGL1, FHL-2, fibrillin-3, Fibroblast Marker, FIR, FLRG, Fussel-18, GDF-11, GDF-9, GDF-9B, gremlin-2, Hic-5, Inhibin β-E, Integrin β8, LOC645781, LOC646862, LRG1, LRRC32, Lumican, MAWDBP1, Myofibroblasts, NOMO2, NPN, NSP3, PCPE-2, Periostin, Procollagen Type III, PTGF-β, Reg lllγ, Smad7, SNIP1, SUSD4, TGF B-1, TGF beta, TGFα, TGFβ2, TGFβ3, TGIF2LX1, TGIF2LX2, TGTP2, TIAF-1, TIMAP, TMEM46, Trichohyalin, Vasorin, WARP, and YKL-39.Activator of:
CD109, CEACAM6, DAF-3, DAF-7, DDR2, FAPα, Integrin α11, Lefty-2, LTBP-1, MAWDBP1, pescadillo, Podocin, SARA, Smad2, Tβ-b, TARSH, TGF B3, TGFβ RIII, TGIF, TGIF2LX, TGIF2LY, TMEM100, TSC-22 D2, uPA, utrophin, and ZNF512.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pirfenidone, 10 mg | sc-203663 | 10 mg | $102.00 | |||
Pirfenidone, 50 mg | sc-203663A | 50 mg | $416.00 |