NS-398 (CAS 123653-11-2)

Estado de Materia :

Solid

Solubilidad :

Soluble in a 1:3 solution of DMSO:PBS(pH7.2) (~400 µg/ml), DMF (~30 mg/ml), DMSO (25 mg/ml), a 2:3 solution of DMSO:PBS (pH 7.2) (2 mg/ml), ethanol(5mg/8ml warm), 100% ethanol (4 mg/ml), methanol, acetone, acetonitrile, and ethanol (0.5 m/ml). Insoluble in water.

Almacenamiento :

Store at room temperature

Punto de Fusión :

127-128° C

Punto de ebullición :

~490.6° C at 760 mmHg (Predicted)

Densidad :

~1.4 g/cm³ (Predicted)

Indice de Refracción :

n²⁰_D 1.59

IC50 :

COX-2: IC₅₀ = 3.8 µM (sheep placental); PGH synthase-2: IC₅₀ = 1 µM; Cyclooxygenase-2: IC₅₀ = 1 nM (Homo sapiens); COX-1: IC₅₀ = 75 µM (human); COX-2: IC₅₀ = 1.77 µM (human); COX-1: IC₅₀ = 220 µM (ovine); COX-2: IC₅₀ = 0.15 µM (ovine); Cyclooxygenase-2: IC₅₀ = <2 nM (Mus musculus); Cyclooxygenase-2: IC₅₀ = 2600 nM (Ovis aries); Cyclooxygenase-1: IC₅₀ = 1670 nM (Mus musculus); Cyclooxygenase-1: IC₅₀ = 3000 nM (Homo sapiens); RAW264.7 (Monocytic-macrophage leukemia cells)RAW264.7 (Monocytic-macrophage leukemia cells): IC₅₀ = 500 nM (Mus musculus)

WGK Alemania :

3

RTECS :

PB0473500

PubChem CID :

Número MDL :

MFCD00882995

SMILES :

CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2