Date published: 2026-7-23

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NF31 (CAS 253426-51-6)

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Alternate Names:
(2-{Ethyl-[4-(4-nitrophenylazo)phenyl]amino}-ethoxy)-acetic acid-4-nitrophenyl ester
Application:
NF31 is a p-nitrophenyl ester that can be employed as a simple and efficient method for the detection of incomplete coupling reactions
CAS Number:
253426-51-6
Purity:
≥97%
Molecular Weight:
493.47
Molecular Formula:
C24H23N5O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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This p-nitrophenyl ester can be employed as a simple and efficient method for the detection of incomplete coupling reactions during solid phase peptide synthesis by visual detection of free amino groups on the resin by direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered primary amines.


NF31 (CAS 253426-51-6) References

  1. EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas.  |  Kaufmann, D., et al. 1999. DNA Cell Biol. 18: 345-56. PMID: 10360836
  2. Evaluation of a two-stage screening procedure in the combinatorial search for serine protease-like activity.  |  Madder, A., et al. 2002. J Comb Chem. 4: 552-62. PMID: 12425599
  3. Validation of a solid-phase-bound steroid scaffold for the synthesis of novel cyclic peptidosteroids.  |  Bodé, CA., et al. 2007. J Pept Sci. 13: 702-8. PMID: 17890641
  4. Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial.  |  Tardif, JC., et al. 2008. Lancet. 371: 1761-8. PMID: 18502300
  5. Towards the conformational mimicry of the measles virus HNE loop: design, synthesis and biological evaluation of a cyclic bile acid-peptide conjugate.  |  Bodé, CA., et al. 2009. Org Biomol Chem. 7: 3391-9. PMID: 19675892
  6. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment.  |  Ren, C., et al. 2013. Eur J Cancer. 49: 3889-99. PMID: 23953057
  7. A novel sensitive colorimetric assay for visual detection of solid‐phase bound amines  |  Madder, A., Farcy, N., Hosten, N. G., De Muynck, H., De Clercq, P. J., Barry, J., & Davis, A. P. 1999. European Journal of Organic Chemistry. 1999(11): 2787-2791.
  8. Fast and easy detection of aromatic amines on solid support  |  Van der Plas, S. E., De Clercq, P. J., & Madder, A. 2007. Tetrahedron letters. 48(14): 2587-2589.
  9. Design and automated generation of artificial estrogen receptor as potential endocrine disruptor chemical binders  |  Figaroli, S., & Madder, A. 2010. Tetrahedron. 66(34): 6912-6918.
  10. Solid‐phase synthesis of aromatic polyamide dendrons  |  Tsushima, H., Matsumoto, K., & Jikei, M. 2011. Polymers for Advanced Technologies. 22(8): 1292-1296.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NF31, 50 mg

sc-286580
50 mg
$353.00

NF31, 250 mg

sc-286580A
250 mg
$1200.00