Lycorine hydrochloride CAS: 2188-68-3
MF: C16H17NO4•HCl
MW: 323.77
A protein synthesis inhibitor.

Lycorine hydrochloride (CAS 2188-68-3)

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Sinónimo: Lycorine chloride
Solicitud: A protein synthesis inhibitor
Número de CAS: 2188-68-3
Pureza: 98%
Peso Molecular: 323.77
Fórmula Molecular: C16H17NO4•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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Lycorine·HCl, originally extracted from Lycoris radiata Herb, has been shown to inhibit viral protein synthesis and peptidyl transferase center. It has been demonstrated that Lycorine-HCL may act at the level of termination to regulate translation of RNA into protein. This compound has been reported to lower the mean arterial pressure in pentobar-bitone-anesthetized normotensive cats and rats. It has also been reported to antagonize the contractile effect of Methoxamine (sc-263468) and depress the hypersensitive effect of pheylephrineon rat anococcygeus muscle and rabbit aorta ring. Additionally, this agent was found to block α 1-adrenoceptors.


References

1. Kukhanova, M., et al. 1983. FEBS Lett. 160: 129-133. PMID: 6350039
2. Vrijsen, R., et al. 1986. J. Biol. Chem. 261: 505-507. PMID: 3001065
3. Chen, B.Y., et al. 1993. Zhongguo Yao Li Xue Bao. 14: 45-49. PMID: 8503287

Apariencia :
Powder
Estado de Materia :
Solid
Solubilidad :
Soluble in water (>15 mg/ml), DMSO, and ethanol.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
210-212° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
164943
Número MDL :
MFCD00243111
SMILES :
C1CN2CC3=CC4=C(C=C3[[email protected]]5[[email protected]]2C1=C[[email protected]@H]([[email protected]]5O)O)OCO4.Cl

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