kynurenine Antibody (11F9): sc-69890

Kynurenine Antibody (11F9) is a mouse monoclonal IgG1 kappa light chain antibody that detects kynurenine in various applications including western blotting (WB) and immunofluorescence (IF). Anti-kynurenine antibody (11F9) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental needs. Kynurenine, a metabolite of the essential amino acid tryptophan, plays a crucial role in several biological processes, including the production of niacin, which is vital for energy metabolism, DNA repair, and the detoxification of harmful substances in the body. The importance of kynurenine extends to its involvement in the synthesis of steroid hormones produced by the adrenal glands, highlighting its significance in maintaining metabolic health. Additionally, elevated levels of kynurenine in plasma have been linked to neurological disorders characterized by involuntary movements, underscoring the need for further research into its physiological and pathological roles. With a molecular mass of 208.2 g/mol, kynurenine is also known to be converted into anthranilic acid through the action of the enzyme kynureninase, which can then participate in organic synthesis pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

kynurenine Antibody (11F9) References:

1. Kynurenine and hydroxykynurenine as precursors of niacin in the rat.  |  D'ANGELI, F., et al. 1956. J Biol Chem. 223: 479-84. PMID: 13376617
2. Kynurenine metabolism in central nervous system in experimental chronic renal failure.  |  Topczewska-Bruns, J., et al. 2003. Adv Exp Med Biol. 527: 177-82. PMID: 15206730
3. Enzyme activities along the kynurenine pathway in mice.  |  Allegri, G., et al. 2003. Adv Exp Med Biol. 527: 497-510. PMID: 15206767
4. Pharmacological manipulation of brain kynurenine metabolism.  |  Reinhard, JF. 2004. Ann N Y Acad Sci. 1035: 335-49. PMID: 15681816
5. Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.  |  Dobrovolsky, VN., et al. 2005. Biochim Biophys Acta. 1724: 163-72. PMID: 15866519
6. Kynurenine--an old pathway retraced.  |  Shader, RI. 2006. J Clin Psychopharmacol. 26: 351-2. PMID: 16855450
7. Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.  |  Forrest, CM., et al. 2006. Clin Exp Pharmacol Physiol. 33: 1078-87. PMID: 17042918
8. Detection of kynurenine modifications in proteins using a monoclonal antibody.  |  Staniszewska, M. and Nagaraj, RH. 2007. J Immunol Methods. 324: 63-73. PMID: 17574268
9. Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.  |  Triplett, TA., et al. 2018. Nat Biotechnol. 36: 758-764. PMID: 30010674
10. IDO/kynurenine pathway in cancer: possible therapeutic approaches.  |  Abd El-Fattah, EE. 2022. J Transl Med. 20: 347. PMID: 35918736
11. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.  |  Zhou, L., et al. 2023. Nat Immunol. 24: 2042-2052. PMID: 37919525
12. Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome.  |  Rickards, H., et al. 1996. Psychol Med. 26: 857-62. PMID: 8817721

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-kynurenine Antibody (11F9) has 5 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

kynurenine Antibody (11F9) Specifications

Alternate Product Name: kynurenine

Product Clone Name: 11F9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: N-formylkynurenine

Epitope Species:

Product Reactivity/Detection: kynurenine modifications in proteins; reacting strongly with N-formylkynurenine-modified N(α)-acetyl histidine

Species Reactivity/Detection: NA

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for kynurenine Antibody (11F9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin