Integrin αM/CD11b Antibody (M1/70): sc-23937

Integrin αM Antibody (M1/70) is a rat monoclonal IgG2b antibody engineered to detect the Integrin αM protein, also known as CD11b, ITGAM, complement component receptor-3 α, Mac-1 α subunit, MAC1A, MO1A, and macrophage antigen a polypeptide. Anti-Integrin αM antibody (M1/70) is raised against T lymphocyte-enriched C57BL/6 mouse spleen cells and demonstrates robust reactivity with Integrin αM from mouse, rat, and human species, making anti-Integrin αM antibody (M1/70) ideal for applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin αM is a vital heterodimeric cell adhesion molecule composed of an αM chain paired with a β2 chain, forming the leukocyte-specific integrin Mac-1 (CR3). Integrin αM undergoes essential post-translational modifications, including N-linked glycosylation, which are critical for proper folding, stability, and ligand-binding capabilities. These modifications play a pivotal role in maintaining the structural integrity of Integrin αM, thereby influencing its ability to interact effectively with cell surface ligands such as intracellular adhesion molecules (ICAMs). This interaction is fundamental for the adherence of neutrophils and monocytes to activated endothelial cells and for the phagocytosis of complement-coated particles. By targeting these functionally significant regions of Integrin αM, anti-Integrin αM antibody (M1/70) ensures reliable detection and analysis in various immunological studies, facilitating advanced research and diagnostic applications that support a deeper understanding of immune cell behavior and function.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.