Integrin αM/CD11b Antibody (3A33): sc-52600

Integrin αM Antibody (3A33) is a rat monoclonal IgG2a antibody specifically engineered to detect Integrin αM, also known as CD11b, ITGAM, Mac-1 α subunit, and complement component receptor-3 α. Anti-Integrin αM antibody (3A33) is raised against mouse Integrin αM derived from peritoneal macrophages of C57 B1/6 x DBA/2 F1 hybrid mice and exhibits strong reactivity with Integrin αM of mouse origin, making it ideal for applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin αM is a critical cell surface adhesion molecule located on the plasma membrane of leukocytes, where it facilitates the adherence of immune cells like neutrophils and monocytes to the endothelium during inflammatory responses. By partnering with Integrin β2, Integrin αM forms the heterodimeric integrin Mac-1 (Macrophage receptor 1) or CR3 (complement receptor 3), which are essential for the phagocytosis of complement-coated particles and the migration of immune cells to sites of inflammation. The precise localization of Integrin αM on the cell surface is crucial for its role in mediating cell-cell and cell-matrix interactions, underscoring its importance in immune surveillance and response. Understanding the expression and regulation of Integrin αM is vital for research into inflammatory diseases, immune cell trafficking, and various pathological conditions involving cell adhesion and migration. Integrin αM monoclonal antibody (3A33) provides researchers with a reliable tool to investigate the molecular mechanisms governing Integrin αM function and its involvement in the immune system. Anti-Integrin αM antibody (3A33) is an essential reagent for scientists studying the pathways of inflammation, host defense, and immune cell behavior, facilitating advancements in immunological research and therapeutic development.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.