Integrin αM/CD11b Antibody (1B6e): sc-21744

Integrin αM Antibody (1B6e) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the Integrin αM protein, also known as CD11b, ITGAM, Mac-1 α subunit, complement component receptor-3 α, p170, macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 α subunit, MAC1A, and MO1A. Integrin αM monoclonal antibody (1B6e) is raised against rat neutrophils and exhibits strong reactivity with Integrin αM from human, mouse, and rat species, making anti-Integrin αM antibody (1B6e) ideal for applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Integrin αM is a crucial heterodimeric cell adhesion molecule composed of an αM chain paired with a β2 chain, forming the leukocyte-specific integrin Mac-1 (CR3). The structural configuration of Integrin αM allows for specific interactions with cell surface ligands like intracellular adhesion molecules (ICAMs), thereby playing a vital role in the adherence of neutrophils and monocytes to activated endothelial cells and facilitating the phagocytosis of complement-coated particles. Understanding Integrin αM′s structure is important because this configuration dictates binding specificity and functional capabilities in immune responses. Integrin αM (1B6e) antibody is available in various forms, including non-conjugated and multiple conjugated versions with agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and several Alexa Fluor® dyes, providing versatility for diverse experimental needs.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αM/CD11b Antibody (1B6e) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αM/CD11b Antibody (1B6e) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αM/CD11b Antibody (1B6e) Specifications

Alternate Product Name: ITGAM

Product Clone Name: 1B6e

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin αM

Epitope Species: rat

Product Reactivity/Detection: Integrin αM

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Integrin αM/CD11b Antibody (1B6e): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.