Integrin α3a/ITGA3A Antibody (158A3): sc-59965

Integrin αIIIa Antibody (158A3) is a mouse monoclonal IgG2a antibody that detects Integrin αIIIa in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). Integrin αIIIa, also known as very late activation antigen 3 (VLA-3), plays a crucial role in cell adhesion and signaling, facilitating interactions between cells and the extracellular matrix. Anti-Integrin αIIIa antibody (158A3) recognizes a protein primarily located on the cell surface, where Integrin αIIIa forms heterodimers with β1 subunits, allowing binding to various ligands, including fibronectin and collagen. Proper localization of Integrin αIIIa is essential for maintaining tissue architecture and mediating cellular responses to the extracellular environment. Integrin αIIIa participates in critical biological processes such as cell migration, proliferation, and differentiation, which are vital for wound healing and immune responses. Integrin αIIIa also undergoes post-translational modifications, including cleavage in the extracellular domain, which is important for functional activation and interaction with other proteins. Integrin αIIIa monoclonal antibody (158A3) enables researchers to gain insights into the dynamics of cell adhesion and signaling pathways, contributing to a better understanding of various physiological and pathological conditions.