Integrin α3/ITGA3/CD49c Antibody (IA3): sc-53355

Integrin α3 Antibody (IA3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin α3 protein of human origin by immunofluorescence (IF). Integrin α3, also known as very late activation antigen 3 (VLA-3), plays a crucial role in cell adhesion and signaling, which are essential for various biological processes such as cell growth, differentiation, migration, and apoptosis. Integrin α3 protein is primarily located on the cell surface, where Integrin α3 forms heterodimers with β1 subunits, allowing interaction with components of the extracellular matrix, including fibronectin, collagen, and vitronectin. Proper localization of Integrin α3 is vital for function, as Integrin α3 facilitates communication between the cell and its environment, influencing cellular responses to external stimuli. Additionally, Integrin α3 undergoes post-translational modifications, including cleavage in the extracellular domain, which results in the formation of disulfide-linked light and heavy chains. These modifications are important for the stability and functionality of the integrin complex, enabling effective mediation of cell adhesion and signal transduction that regulate critical cellular functions. Anti-Integrin α3 antibody (IA3) is an invaluable tool for researchers studying the dynamics of cell adhesion and signaling pathways in human cells.

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Integrin α3/ITGA3/CD49c Antibody (IA3) References:

1. A peptide of the alpha3 chain of type IV collagen protects basement membrane against damage by PMN.  |  Ziaie, Z., et al. 1999. Biochem Biophys Res Commun. 261: 247-50. PMID: 10425173
2. Loss of VLA-3 (CD49c/CD29) expression in two multidrug resistant Burkitt's lymphoma cell lines.  |  Duensing, S., et al. 1998. Cancer Biother Radiopharm. 13: 369-73. PMID: 10851427
3. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.  |  Sigle, RO., et al. 2004. J Cell Sci. 117: 4481-94. PMID: 15316072
4. Oncothanin, a peptide from the alpha3 chain of type IV collagen, modifies endothelial cell function and inhibits angiogenesis.  |  Shahan, T., et al. 2004. Connect Tissue Res. 45: 151-63. PMID: 15512769
5. Differential expression of very late activation antigen-3 (VLA-3)/VLA-4 in B-cell non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia.  |  Baldini, L., et al. 1992. Blood. 79: 2688-93. PMID: 1586717
6. Loss of integrin alpha3 expression associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells.  |  Suzuki, N., et al. 2005. Hum Cell. 18: 147-55. PMID: 17022147
7. Integrin alpha3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression.  |  Wen, T., et al. 2010. Wound Repair Regen. 18: 325-34. PMID: 20412552
8. Integrin α3 blockade enhances microtopographical down-regulation of α-smooth muscle actin: role of microtopography in ECM regulation.  |  Ayala, P. and Desai, TA. 2011. Integr Biol (Camb). 3: 733-41. PMID: 21666923
9. Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations.  |  Colombo, EA., et al. 2016. Orphanet J Rare Dis. 11: 136. PMID: 27717396
10. Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells.  |  Wang, SH., et al. 2019. Int J Cancer. 144: 2795-2810. PMID: 30485433

The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.